Biomedical Research

Introduction: The long-term results of intracranial aneurysms treated with a Neuroform stent have been not reported. This study was to investigate the long-term evolution of intracranial aneurysms treated with the Neuroform stent and in-stent stenosis.

Materials and Methods: Fifty-one patients with sixty-four intracranial aneurysms underwent Neuroform stent deployment over ten years. Angiographic data were compared before treatment and at each followup.

Results: Forty-six aneurysms were treated with stent-assisted coiling while eighteen with stent deployment alone, with a total procedure-related complication rate of 6.7%. Immediate occlusion of the forty-six aneurysms with stent-coiling was complete in thirty-four aneurysms (73.9%), near complete in ten (21.7%) and incomplete in two (0.4%). During follow-up of 89 months (mean 52), twenty-three (71.9%) of 32 aneurysms with initial complete occlusion and follow-up remained completely occluded while nine (28.1%) recurred. Among ten aneurysms with initial near complete occlusion, one remained unchanged, four recurred and were re-treated to complete occlusion, and the other five had progressive thrombosis to complete occlusion. All fifteen aneurysms with stenting alone decreased in size with eight aneurysms completely disappeared. Progressive thrombosis occurred in twenty-two cases (81.5%) and of forty-two aneurysms with complete or near complete occlusion, recurrence occurred in thirteen cases (31%). Mild asymptomatic in-stent stenosis was present in three cases (5.3%).

Conclusion: Stent reconstruction is safe in treating intracranial aneurysms with mild in-stent stenosis rate at long-term follow-up.

Author(s): Chun-Yan Zhu, Cun-Xiang Liu, Ji-Xiang Liu, Tao Zhou, Cong-Hui Li, Song-Tao Yang, Bu-Lang Gao
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