Biomedical Research

Objective: To observe and analyse the effect of percutaneous penetration of bone cement augmentation on the treatment of osteoporotic compressive fracture and bone non-union and explore its safety.

Methods: Subjects in the study were 60 cases of osteoporotic vertebral compression fractures with bone non-union in our hospital. All of these patients received treatment from May 2014 to May 2017 and underwent targeted puncture under local anesthesia and imaging surveillance with the bone end of nonunion augmented with cemented bone. Visual Analogue Scale (VAS) and Activities of Daily Living (ADL) score were adopted to assess the patient’s conditions in the day before surgery, the day after surgery, and the third, eighth and twelfth month after surgery and observe the effect of treatment.

Results: In this study, 40 patients, including 43 vertebral bodies, underwent successful operations and were observed intensively after surgery. Radiographic findings showed no leakage of cemented bone. Compared with patients’ condition in the day before surgery, their VAS score comparatively decreased in the day after surgery, and the third, eighth and twelfth month after surgery of statistical significance. The VAS score of the twelfth month was much lower than that of the third month. For the ADL score, it turned out that the score in the third, eighth and twelfth month after surgery was apparently higher than that before surgery. In addition, after comparing the anterior and posterior vertebral height before and after surgery, we concluded that the results showed no statistical significance.

Conclusion: For the treatment of osteoporotic compression fracture and bone non-union, percutaneous targeted bone cement augmentation therapy can achieve relatively satisfactory results. Moreover, it is safe and reliable, and it is of great value to be popularized and applied.

Author(s): Liu Yang, Liying He, Jun-ming Cao, Yongsheng Lin, Xiangbei Qi, Zhihong Wang, Yipeng Yang
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