Biomedical Research

Objective: To investigate the value of early lactate dynamic monitoring index in predicting prognosis of patients with sepsis and septic shock.

Methods: From November 2013 to November 2016, 62 cases of sepsis and septic shock patients enrolled in our hospital were selected as the objects. The basic personal information of all patients was recorded immediately after their admission followed by APACHE score. Blood lactate tests were performed at 6 h after admission. After 28 d of treatment, the treatment outcome was documented, according to which the patients were divided into success group and failure (death) group, the prediction effect on the prognosis of the patients of lactic acid dynamic monitoring was compared between the two groups.

Results: The statistical data and comparative analysis showed that 28 d after admission, 19 from 62 patients died. The SOFA and APACHE score of failure group both increased and lactate clearance rate was moderately low, and in the stage of T24, the concentration of lactic acid turned out to increase significantly while the corresponding lactate clearance rate greatly decreased in which the difference was statistically significant (P<0.05). The result of logistic regression analysis showed the main risk factors associated with the prognosis of patients were the lactic acid clearance rate and APACHE II score in T24.

Conclusion: The early lactate dynamic monitoring index has high value in predicting the prognosis of sepsis and septic shock patients, thus worth popularizing.

Author(s): Shijie Liu, Haijun Cao, Xiangdong Xu, Haipeng Sun, Shaoxia Qu, Yunbo Sun
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