Biomedical Research

The value of pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio(PLR) in predicting survival in patients undergoing hepatectomy for hepotocelluar carcinoma was assessd. We conducted a retrospective analysis of 80 patients who underwent hepatectomy for hepatocellular carcinoma. Data of haematological laboratory values as well as demographics and histopathology were collected. Univariate and multivariate analyses were applied. Pretreatment high NLR was associated with shorter overall survival (OS)(P=0.034). Pretreatment high PLR was linked with shorter overall survival and disease-free survival (DFS)(P=0.038 and P=0.020). The patients with both high pretreatment NLR and PLR had shorter median OS and DFS than those with both low pretreatment NLR and PLR (P=0.026 and P=0.015). On multivariate analyses, pretreatment NLR (P=0.008), tumor–node–metastasis (TNM) stage (P=0.003), capsule invasion (P=0.025) and tumor differentiation (P=0.000) were independent of prognostic factors for overall survival. Pretreatment PLR (P=0.040), TNM stage (P=0.003) and tumor differentiation (P=0.011) were independent of prognostic factors for disease-free survival. Pretreatment high NLR and PLR might be potential biomarkers in cases of poor prognosis for patients undergoing hepatectomy for hepatocellular carcinoma.

Author(s): Qiong Sun, Shun-Chang Jiao, Jian-Yu Wu, Yan-Yan Long, Li Chen
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