Background and aims: To study the prevalence of depression among a sample of clinical and subclinical
hypothyroid patients, in addition to the correlation between thyroid-stimulating hormone and depression
severity.
Study design: A cross-sectional study in Al Mouwasat University Hospital, Damascus, Syria.
Materials and methods: A total of 114 patients diagnosed with hypothyroidism were evaluated by interview
using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria.
Results and conclusion: The prevalence of depression among patients with hypothyroidism (either clinical
or subclinical) was 31.57%. Higher depression rates were observed in clinical hypothyroidism patients
compared with subclinical hypothyroidism patients. In addition, depression severity was also higher in
the clinical hypothyroidism group. Increased rate and severity of depression with increased TSH levels.
However, the rate and severity of depression are inversely proportional to the duration of the diagnosis of
hypothyroidism.
Author(s): Ahed Hamed, Nazht Nmr, Nawras Alhalabi, Rima Tayfour, Youssef Latifeh
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