Biomedical Research

Frontal lobe epilepsy (FLE) surgery is the second most likely pharmacoresistant focal epilepsy benefitting from surgical treatment secondary to temporal lobe epilepsy (TLE). This study aims to investigate the clinical characteristics of frontal lobe epilepsy and analyze the factors associated with the prognosis of surgery. 27 patients confirmed with frontal lobe epilepsy by surgery from 2010 to 2014 were enrolled in this study. The clinical characteristics of frontal lobe epilepsy and the epileptogenic focus position were analyzed. Engel and International League Against Epilepsy (ILAE) classification were used for prognostic analysis. The prognosis of 17 (63%) patients reached Engel class I, and that of 15 (56%) patients reached ILAE class I. The prognosis of patients with epileptogenic focus resection was better than lesion disconnection and thermocoagulation, but no significant difference. The epileptogenic focus position and negative magnetic resonance imaging (MRI) were not the factors for surgical prognosis. The prognosis of frontal lobe epilepsy is overall good. The preoperative assessment of individual and complete resection of lesion is the key for surgical prognosis.

Author(s): Jun Gao, Jianguo Shi, Huili Jiang, Bin Du, Xiang Fang
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