Biomedical Research

Objectives: To discuss relationship between murine cytomegalovirus infection and late-onset vitamin K deficiency intracranial hemorrhage.

Methods: Twenty healthy mice were randomly divided into control group (n=10) and cytomegalovirus infection model group (n=10). The changes of biochemical indexes such as PT, APTT, FIB and serum TBil, DBil, GGT and TBA were measured and compared at 2 months and 4 months of age.

Results: At the age of 2 months and 4 months, the levels of PT, APTT, TBil, DBil, TBA, GGT and AST in the cytomegalovirus infection group were significantly higher than those in the control group (P<0.05). There was no significant difference in the levels of FIB and ALT between the two groups (P>0.05).

Conclusion: Cytomegalovirus infection can lead to abnormal blood coagulation and serum biochemical indicators in mice, induced vitamin K deficiency in the occurrence of intracranial hemorrhage.

Author(s): Lin Jin, Qiang Liu, Lechi Zhang
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