Biomedical Research

This study aimed to investigate the effect of Overweight (OW)/Obesity (OB) on Microalbuminuria (MAU). According to the level of Urine Albumin-to-Creatinine Ratio (UACR), 1170 cases are divided into the Normal Albumin Urine (NAU) group (men: 398 cases, women: 409 cases) and MAU group (men: 175 cases, women: 188 cases). The clinical data and biochemical indexes of the study participants were obtained. Statistical analysis was performed using the SPSS16.0 software. The result of the multiple linear regression analysis depicted that age, Diastolic Blood Pressure (DBP), Fasting Blood Glucose (FBG), Waist-to-Hip Ratio (WTHR), Waist Circumference (WC), and Waist-to-Height Ratio (WHR) were significantly associated with UACR. After the modification of age, sex, FBG, and DBP, the contribution of different variables to MAU showed that WTHR>WC>WHR. By using the Receiver Operating Characteristic curve (ROC) analysis in the male population, the incidence rates of the areas under the curve of WTHR, WHR, and WC used to predict MAU were 0.68 (95% CI: 0.67-0.70), 0.64 (95% CI: 0.62-0.65), and 0.57 (95% CI: 0.55-0.59), respectively, and the predictive points were 0.52, 0.90, and 91.8 cm. In the female population, the incidence rates of the areas under the curve of WTHR, WHR, and WC used to predict MAU were 0.71 (95% CI: 0.70-0.72), 0.69 (95% CI: 0.68-0.70), and 0.64 (95% CI: 0.62-0.65), respectively, and the predictive points were 0.52, 0.8, and 82.5 cm. The AOB population was at high risk for MAU. WTHR was the best predictor, followed by WC and WHR. The cut-off points in men and women are 0.52, 89.6 cm, and 0.88 and 0.52, 84.5 cm, and 0.84 cm, respectively.

Author(s): Xiaopang Rao, Weizhan Huang, Yanyan Xu, Xiujuan Li, Meiyan Wan
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