Biomedical Research

Objective: To explore relevant risk factors of lymph node metastasis in central zone of Papillary Thyroid Microcarcinoma (PTMC) in patients, which will provide a certain clinical basis for lymph node dissection surgery in central zone selectively.

Method: Clinical data of 150 PTMC patients (recurrence cases because of surgery were excluded) with surgical treatment in Qilu hospital of Shandong university from October 1st, 2011 to January 30th, 2013. Independent risk factors of lymph node metastasis in central zone were given retrospective analysis.

Results: Total metastasis rate of PTMC in central zone was 35.3% (53/150). Single factors analysis show that size of tumor, whether had envelope invasion, clinical typing cN1 patients had close relations with lymph node metastasis in central zone, P<0.05; multiple factors analysis show that size of tumor (OR=2.466, P=0.010), envelope invasion (OR=1.632, P=0.005), clinical typing (OR=2.070, P=0.001) were independent risk factors of lymph node metastasis in central zone; lymph node metastasis rate in central zone of patients without three independent factors was 16.3%, 7/43, which lower than patients with any one risk factor (43.0%, 45/107) obviously, P=0.002.

Conclusion: Size of tumor, tumor invading envelope, clinical typing cN1 are independent risk factors of lymph node metastasis in central zone. Patients who have relevant risk factors should be given lymph node dissection in central zone.

Author(s): Yufei Wang, Jie Han, Yuetao Lv, Guochao Zhang
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