Biomedical Research

Objective: To explore risk factors of colorectal cancer and its clinical epidemiological study.

Methods: This study analysed clinical data of 1860 colorectal cancer patients retrospectively, its epidemiological characteristics, compared them with 1725 non-tumor patients, risk factors which caused colorectal cancer.

Results: There were significant differences in sex (χ²=204.404, P<0.05), age (χ²=-0.208, P<0.05), years (χ²=4.254, P<0.05), primary focus location (χ²=73.050, P<0.05) and pathological type distribution (χ²=22.066, P<0.05) of colorectal patients; there were significant differences in basic diseases (χ²=35.623, P<0.05; χ²=13.359, P<0.05), colorectal cancer family history (χ²=18.628, P<0.05), cholecystectomy history (χ²=27.420, P<0.05), appendectomy between patients in colorectal group and the control group (P<0.05), which given single factor and multiple factors logistic analysis, it was found that diabetes, hypertension, colorectal cancer family history and appendectomy all can be risk factors which induced colorectal cancer. Diabetes (OR 95% CI=1.019-2.299, P=0.039) and colorectal cancer family history (OR 95% CI=3.769-21.380, P<0.001) were the main risk factors which induced colorectal cancer.

Conclusion: The high group of colorectal cancer are male. The onset age is mainly middle and old age group. Primary focal location is mainly in rectum. Pathological type is canal adenocarcinoma mostly. Diabetes and colorectal cancer family history are main risk factors which induced colorectal cancer.

Author(s): Yi Liu, Wen bin Ding, Chengqiu Yan, Han Bao, Kai Li, Cheng Wang
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