Biomedical Research

Preeclampsia (PE) a pregnancy specific disorder is the most common cause of fetal and maternal death yet no specific prevention and treatment is available. Reliable biochemical markers for prediction and diagnosis of PE can have a better impact on maternal health and several of the markers have been suggested till now. Recently Ischemia Modified Albumin (IMA) has emerged as a marker in different diseases where ischemia is the origin or consequence behind disease pathology. Therefore this study was undertaken to evaluate the role of maternal serum IMA in PE and its correlation with the oxidative stress. 45 patients with PE were selected for the study and compared with 31 pregnant healthy controls. IMA IMA/Albumin and Malondialdehyde (MDA) with other routine biochemical markers were estimated in these patients. The results were then statistically analysed. IMA levels were found significantly raised in PE patients as compared to normal pregnant controls (p value <0.001). A significant correlation was also found between IMA levels and MDA levels in PE (r =+0.3 p value <0.05). Thus we conclude that IMA generated by hypoxia/ischemia driven oxidative stress is also raised in PE hence can be used as a biomarker in PE. Further studies are needed to establish the relationship between IMA and disease process and its association with severity of disease. Keywords: Preeclampsia Ischemia Modified

Author(s): Jyotirmayee Bahinipati, Prakash Chandra Mohapatra, Tapaswini Pradhan
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