Biomedical Research

The role of Tumor Necrosis Factor alpha, Malondialdehyde and serum Iron in inducing anemia in Tuberculosis patients was studied. The present study was conducted in the De-partment of Biochemistry, Shri Aurobindo Institute of Medical Sciences, Indore. The study comprised of sixty-eight anemic pulmonary tuberculosis patients. Levels of Hemoglobin, Iron, TIBC, Ferritin, MDA & TNF α were analyzed in all of them. The inflammatory pa-rameters TNF α & Ferritin along with oxidative marker malondialdehyde were found to be increased in anemic tuberculosis patient and levels of Hb, iron & TIBC was decreased. Overall correlation shows that the levels of Hb, Iron & TIBC were negatively correlated to the levels of Ferritin, MDA & TNF α. Ferritin was negatively correlated with Iron (r = -0.261, p<0.05) & showed a positive correlation with MDA. (r = 0.304, p < 0.05). For Ferritin & TNF α correlation was positive, it was not significant (r = 0.114, NS).There was a positive significant correlation between Iron & TIBC. (r = 0.666, p<0.01) & a negative significant correlation between the TNF α levels and the hemoglobin concentration (r = -.273, p<0.05). Hypoferremia was induced as a consequence of inflammatory response and action of free radicals in anemic tuberculosis patients

Author(s): Rashmi kulkarni, Ajit Deshpande, Kiran Saxena, Akhouri R Sinha4, Meena Verma. Ravi Saxena
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