Biomedical Research

Introduction: In this study, we aimed to retrospectively investigate the relationship of the clinical and hematological parameters with malignancies in patients with anemia.

Patients and Methods: Between January 2012 and February 2014, 54385 patients admitted to our emergency clinic. Of this population 1047 had anemia and were eligible for inclusion criterion to the study. Hematologic parameters of patients counted in an analyzer device (CELL-DYN 3700, Abbott Diagnostics, Abbott Park, IL, USA).

Results: According to the final diagnoses made in the admission clinics, the patients were grouped into malign and benign. One hundred and sixty-six (15.8%) patients were grouped as malign and 881 (84.2%) as benign. Malign group was older and had a greater male percentage than benign group. MPV and sedimentation rate were significantly higher in the malign group. Hemoglobin, hemotocrit, erythrocyte and platelet count were significantly lower in the malign group. In logistic regression analysis the independent predictors of malignancies were MPV (odds ratio (OR)=1.206; 95% confidence interval (CI)=1.050-1.386; p=0.008), age (OR=1.028; 95% CI=1.018-1.037; p<0.001), male gender (OR=1.835; 95% CI=1.197-2.814; p=0.005), and hemotocrit (OR=0.837; 95% CI=0.712-0.962; p=0.004).

Conclusion: Our study showed that age, male sex, hematocrit, and MPV were the on the population level statistically significant independent predictors of malignancies in patients diagnosed with anemia in emergency department.

Author(s): Ercan Gunduz, Hasan Mansur Durgun, Mehmet Günduz, Mehmet Ozen
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