Biomedical Research

Objective: To investigate the epidemiology and influential factors of nosocomial pulmonary infection in type 2 diabetes mellitus (T2DM) patients complicated with malignancies.

Methods: 316 T2DM patients complicated with malignancies in our hospital were selected as the research objects from February 2015 to June 2017. Among them, 36 cases had pulmonary infection in the hospital. We firstly investigated the epidemiology, then Pearson correlation analysis and multivariate logistic regression analysis were adopted respectively to analyze the related factors of nosocomial pulmonary infection in T2DM patients complicated with malignancies.

Results: According to the epidemiological investigation, in T2DM patients complicated with malignancies, the nosocomial pulmonary infection rate in aged patients (≥ 60 years old) was significantly higher than that in younger patients (<60 years old, P<0.05); the infection rate in male patients was significantly higher than that in female patients (P<0.05); the longer course of diabetes, the higher rate of nosocomial pulmonary infection (P<0.05); the higher of the BMI level, the higher rate of nosocomial pulmonary infection (P<0.05); the infection rate in rural patients was significantly higher than that in city patients (P<0.05); the infection rate in manual workers was significantly higher than that in mental workers (P<0.05); the higher level of education, the lower rate of nosocomial pulmonary infection (P<0.05); no significant relationship was found between fasting plasma glucose (FPG) level and nosocomial pulmonary infection rate (P>0.05). Through Pearson correlation analysis and multivariate logistic regression analysis, we finally got the related factors of nosocomial pulmonary infection in T2DM patients complicated with malignancies, including age, impaired respiratory function, and chronic diseases.

Conclusion: The nosocomial pulmonary infection in T2DM patients complicated with malignancies had a certain epidemiological characteristics and was affected by age, impaired respiratory dysfunction and chronic diseases and effective measures should be taken to prevent it.

Author(s): Xiaoyang Song, Hongyan Yao, Qiang Wang, Ying Mao, Jinlin Liu, Jingxian Wu
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