Biomedical Research

Objective: To study and analyse changes of serum CXCL12 in patients with acute cerebral infarction and its clinical significance.

Methods: According to diagnosis criteria and exclusive conditions, 60 patients with acute cerebral infarction first had been diagnosed by clinic were recruited as experimental group. 60 healthy physical examination whose clinical indexes had no statistical differences compared with experimental group as the control group. ELISA used to detect concentration of CXCL12 in serum for subjects in two groups. Color Doppler ultrasound used to detect CIMT thickening of cervical vessels and quality of plaque.

Results: Concentration of serum CXCL 12 in experimental group higher than the control group, differences had statistical significance (P<0.05). Concentration of serum CXCL 12 of CIMT thickening in the experimental group and the control group all not obviously higher than CIMT normal group, differences had no statistical significance (P>0.05). Concentration of serum CXCL 12 of unstable plaque group in the experimental group obviously higher than non-plaque group and stable plaque group, differences had no statistical significance (P>0.05). Concentration of serum CXCL 12 of stable plaque group not obviously higher than non-plaque group, differences had no statistical significance (P>0.05). Concentration of serum CXCL 12 concentration of unstable plaque group in the control group obviously higher than non-plaque group and stable plaque group, differences had no statistical significance (P>0.05). Concentration of serum CXCL 12 of stable plaque group not higher than non-plaque group, differences had no statistical significance (P>0.05).

Conclusion: Results of this study show that serum CXCL12 participates in ischemic injury process of acute cerebral infarction, also involves in unstable plaque of cerebral infarction patients. But it has no relations with tunica media thickness in artery. Serum CXCL12 level can be an important biological index for evaluating prognosis of acute cerebral infarction, it will be benefit for giving early pathogenesis types for clinical doctors on cerebral infarction patients, confirming pathogenesis to guide clinical treatment, judging prognosis and giving proper prevention in the second level.

Author(s): Zhang Feng, Wang Min, Wang Dong
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