Biomedical Research

To investigate the effect of surgical treatment of hydrosalpinx on the expressions of estrogen receptor (ER) and progesterone receptor (PR) in the endometrium in implantation window, a total of 60 patients with hydrosalpinx and 30 patients with fallopian tube obstruction were recruited. In the implantation window, immnohistochemistry was carried out to detect the expressions of ER and PR in the endometrium of the hydrosalpinx patients before and after surgery and of patients with fallopian tube obstruction. In the implantation window, the expressions of ER and PR in the endometrium of hydrosalpinx patients before surgery were significantly lower than those in patients with fallopian tube obstruction (P<0.05). However, there were no significant differences in the expressions of ER and PR in the implantation window between hydrosalpinx patients after surgical intervention and fallopian tube obstruction patients (P>0.05). Furthermore, for patients with hydrosalpinx, the expressions of ER and PR in the implantation window were dramatically increased after surgery (P<0.05). Hydrosalpinx reduces the expressions of ER and PR in the endometrium in the implantation window, which can be improved by surgical intervention.

Author(s): Yiping Zhong, Jin Li, Haitao Wu, Ying Ying, Yafeng Liu, Canquan Zhou, Yanwen Xu, Xiaoting Shen, Quan Qi
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