Biomedical Research

Aim: The purpose of this study was to seek the acute effects of coffee intake on glucose metabolism and some hormones.

Materials and Methods: The participants were asked to drink a cup of instant coffee (2 g). Three hours later, the glucose, insulin, glucagon, leptin, cortisol, total cholesterol, triglyceride, HDL, LDL, CRP, TSH and free T4 tests were repeated. The participants did not consume any other drink or food between 0 and 3 h. The participants were called back one week later. In 0 h, the glucose, insulin, glucagon, leptin, cortisol, total cholesterol, triglyceride, HDL, LDL, CRP, TSH and free T4 tests were performed. This time, the participants were asked to drink a glass of hot water. Three hours later, same tests were repeated.

Results: There weren't any significant changes in the levels of insulin, glucagon, cortisol, lipid levels, CRP, TSH and free T4 tests after coffee intake but we found significant changes in the leptin and plasma glucose values.

Conclusions: In conclusion, acute coffee intake does not have an acute impact on glucagon, cortisol, and TSH levels but affects leptin levels which can be one of the mechanisms of type diabetes mellitus reduction with coffee intake.

Author(s): Ugur Bilge, Ilhami Unluoglu, Gozde Gultekin Sari, Nehir Ozgul Mengulluoglu, Nazife Sule Yasar Bilge, Muzaffer Bilgin
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