Biomedical Research

Background: Our objective is to explore the effect of multi-modal analgesia on postoperative pain and nosocomial infection in patients with lower limb fracture.

Methods: 84 patients with lower limb fracture were selected. The Visual Analogue Scale (VAS) scores, adverse reactions and the incidence rates of nosocomial infection after surgery were observed and compared.

Results: The VAS scores at 1 h, 2 h, 24 h, 2 d and 3 d after surgery in the control group were 7.5 ± 0.32, 5.4 ± 0.38, 3.8 ± 0.42, 1.8 ± 0.54 and 1.5 ± 0.25 respectively, which were 6.3 ± 0.28, 3.8 ± 0.29, 2.4 ± 0.48, 1.3 ± 0.32, 1.1 ± 0.36 in the observation group respectively, there were significant difference between two groups (p<0.05). The incidence rates of postoperative adverse reactions such as respiratory depression, headache, nausea, vomiting and somnolence was 45.2% in the control group and 19.1% in the observation group, there was significant difference between two groups (p<0.05). The rates of nosocomial infection was 40.4% in the control group and 14.4% in the observation group, there was significant difference between two groups (p<0.05).

Conclusions: In conclusion, the effect of multi-modal analgesia is significantly better than the single conventional analgesia mode in patients with lower limb fracture.

Author(s): Hong-Bo Li, Shou-Hui Xu
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