Biomedical Research

Background/aims: Chronic Viral Hepatitis B (CVHB) disease is a major health problem in our country and the world. Liver biopsy is still the gold standard today to show liver fibrosis and necroinflammatory activity. Liver biopsy is an invasive procedure. Therefore, in recent years, the development of non-invasive and practical testing has gained importance to show liver fibrosis In this study, it was aimed to compare the results of APRI, AP index, FIB-4, AAR panel tests with the degree of liver fibrosis.

Materials and Methods: 150 naive CVHB patients who were conducted percutaneous liver biopsy examined retrospectively. The following non-invasive tests (APRI, APindex, FIB-4, AAR) were calculated and they were compared with the fibrosis score.

Results: It was statistically significant between an increase in FIB-4 score and an increase in the degree of fibrosis (P=0.03). FIB-4 values ≥ 3.25 and it was considered significant to show the disease. It was statistically significant between an increase in AP index score and an increase in the degree of fibrosis (P=0.015)

Conclusion: It is considered that non-invasive tests are quite useful in showing the status of liver fibrosis in patients with CVHB.

Author(s): Yahya Atayan
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