Biomedical Research

Background: To compare the differences of organism redox state in AIDS patients complicated with tuberculosis and tuberculosis patients.

Methods: Subjects were divided into two groups, AIDS and TB group (n=40) and TB group (n=40) with 30 healthy subjects as the control group. Based on the measurement of reduced Glutathione (GSH) and oxidized glutathione (GSSG) as well as NADPH and NADP, the ratios of GSH/GSSG and NADPH/ NADP were used to describe the redox state of patients and compare the organism redox state in two groups.

Results: The levels of GSH, GSSG, GSH/GSSG, NADPH, NADP+, NADPH/NADP+ in AIDS and TB group, TB group and control group were different (F=115.0, P<0.01, F=3944.0, P<0.01, F=1957.0, P<0.01, F=318.0, P<0.01, F=318.0, P<0.01, F=12.0, P<0.01, F=104.0, P<0.01).

Conclusion: There is a difference in the redox state of AIDS patients complicated with tuberculosis and tuberculosis patients.

Author(s): Qingxi Wang,Zemin Wang
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