Biomedical Research

In this study, we investigated the effects of lacidipine on XO, MDA, MPO, and GSH levels in ovarian tissues of rats, which are subjected to ischemia and post-ischemic reperfusion. In ovarian ischemia (OI), ovarian ischemia-reperfusion (OIR), 2 mg/kg lacidipine + ovarian ischemia (LOI-2), 4 mg/kg lacidipine + ovarian ischemia (LOI-4), 2 mg/kg lacidipine +ovarian ischemia-reperfusion (LOIR-2), 4 mg/kg lacidipine + ovarian ischemia-reperfusion (LOIR-4) and sham-operated healthy control group (HCG); XO 23.8±0.94, 13.6±0.76, 8±0.57, 5.8± 0.60, 4.5± 0.42, 3.6±0.55, 2.8± 0.30 u/g, respectively, whereas MDA, 4.8±0.47, 13.33± 0.66, 3.5±0.35, 3.4±0.42, 6.0±0.57, 5.3±0.61,2.8± 0.22 μmol/g protein, respectively . MPO, 6.1± 0.60, 14.1± 0.94, 6.3± 0.66, 6.0± 0.73, 8.8± 0.60, 7.5± 0.76, 6±1.06 u/g protein, respectively, while GSH 8.0±0.73, 3.1±0.47, 8.6±0.95, 8.9±0.91, 7.1±0.60, 7.5±0.76 ,9.1±0.47 nmol/g protein, respectively. The present study, conducted on the basis of the mechanism of formation of IR injury, demonstrated that lacidipine prevents ischemia-reperfusion injury in the ovarian tissues.

Author(s): Serkan KUMBASAR, O.Erkan YAPCA, Habib BILEN, Bahadir SULEYMAN, F. Betul OZGERIS, Bunyamin BOREKCI, Halis SULEYMAN
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