Biomedical Research

Objective: To compare the effect of minimally invasive operation and open surgery on the serum interleukins (IL-1β) and matrix metalloproteinases (MMP-1, MMP-13) of patients with senile spinal tuberculosis (SST) and perioperative nursing.

Methods: 85 patients with SST in our hospital from September 2015 to October 2017 were collected into this study, including 40 patients in the control group with the open surgery and 45 patients in the observed group with the minimally invasive operation. The results of clinical efficacy, the bleeding volume, the operation time, the hospital stay, the incidence of complications, the serum values of IL-1β, MMP-1, MMP-13, and satisfaction were compared between the control group and observed group.

Results: The total efficacy rate and satisfaction of patients in the observed group were respectively 93.33% and 95.56%, which were more than the control group (P<0.05). After the surgery, the bleeding volume, the operation time, the hospital stay and the incidence of complications were less than the control group (P<0.05). The serum values of IL-1β, MMP-1, MMP-13 after surgery in both groups were lower than before treatment (P<0.05), and the serum values of IL-1β, MMP-1, MMP-13 after surgery in the observed groups were lower than the control group (P<0.05).

Conclusion: It’s suggested that minimally invasive operation decrease the complications, improve the clinical symptoms and satisfaction of SST patients, which is worthy to be clinically popularized.

Author(s): Gao Di, Feng Chao, Zhuang Huirong
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