Biomedical Research

Objective: To explore the effect of Multi-oil Fat Emulsion (SMOF) in perioperative parenteral nutritional support on older patients with gastric cancer.

Methods: 120 patients with gastric cancer were evenly and randomly assigned to Control, Intralipid and SMOF group. Nutritional status, immune function and liver function in three groups were compared among 0 dpo (day post operation), 3 dpo and 7 dpo. Complications, length of stay and hospital costs were analyzed, as well.

Results: Significant differences were observed in nutritional status, immune function and liver function among three groups during perioperative period. After surgery, ALB, PAB, TF in Intralipid and SMOF group were significantly higher than in that Control group (P<0.01). CD3, CD4, CD4/CD8, IgA, IgG, IgM levels after surgery in SMOF group were significantly higher than in that Control and Intralipid group (P<0.05). CRP and IL-6 and TBIL levels of 7 dpo in SMOF group were significantly lower than other two groups, especially Intralipid group (P<0.01). SMOF group had the lowest complication incidence (P<0.05).

Conclusion: SMOF in perioperative parenteral nutritional support contributes to older gastric cancer patients with significantly improved immune function, reduced complications and without increasing hospital costs. A Cohort study with greater patient numbers is needed.

Author(s): Hui Chen, Dun Pan, Liangqing Li
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