Biomedical Research

Objective: To explore the expression and significance of CD28, ctla-4, CD80 and CD86 in ankylosing spondylitis.

Methods: Flow cytometry was used to test in January 2016-January 2017 in our hospital was 73 cases of ankylosing spondylitis patients and 40 normal controls CD28, CTLA 4, CD80 and CD86 weeks outside expression in lymphocytes. By ELISA method, the lgA serum immunoglobulin IgG, IgM and hypersensitive c-reactive protein (hs CRP) and blood sedimentation (ESR) levels, and to explore, CD80, CD86 and CD28, CTLA - 4, age, duration of the hs CRP, ESR, Bath AS functional index (BASFI) and Bath AS measurement index (BASMI) relevance.

Results: The levels of CD28, ctla-4, CD80 and CD86 were significantly higher in patients with ankylosing spondylitis (P<0.05). The levels of IgG and IgA in patients with ankylosing spondylitis were higher than those in the control group, and the difference was statistically significant (P<0.05). The CD28 level of peripheral blood was positively correlated with ESR and BASFI index (P<0.05), which was negatively correlated with hs-crp and BASMI index (P<0.05). The ctla-4 has negative correlation with ESR, hs-crp and BASMI index (P<0.05), and has no relationship with the BASFI index. CD80 was negatively correlated with ESR, BASFI index and BASMI index (P<0.05), and had no relationship with hs-crp. CD80 has positive correlation with hs-crp and BASMI index (P<0.05), which has no relation with ESR and BASFI index.

Conclusion: The patients with ankylosing spondylitis is a total stimulus molecular CD28, CTLA 4, higher CD80, CD86 clear expression, the body is in a state of immune activation, has close relationship with immune dysfunction, monitoring peripheral CD28, CTLA 4, CD80, CD86 level is helpful for the early detection of disease, determine the illness treatment strategy.

Author(s): Wanglei Du, Linxuan Pang, Yanna Ba, Tingting Lv, Zhaohui Zheng, Xueyi Li, JIN Ding, Guangzhi Xiao, Ying Li, Ronghua Xie, Ping Zhu, Xichao Yang, Zhenbiao Wu
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