Biomedical Research

Objective: To use Wuling capsule drugs to give intervening treatment for change and generation mechanism of the patients with post-stroke fatigue.

Methods: 140 cases of fatigue patients post stroke treated in our hospital were randomly divided into two groups: control group and observation group, 70 cases in each group. The control group was treated with oral vitamin C, the observation group was treated with Wuling capsule, and the quality of life and the degree of changes of inflammatory cytokines in patients with fatigue the brain after stroke were analysed and compared.

Results: compared with the control group, the expression levels of inflammatory cytokines IL-1β and IL-10 in the observation group were significantly decreased, the expression of IL-9 increased significantly, the difference between groups was significant (t=6.552, t=5.844, P<0.05); the Barthel index score increased significantly, there is a statistically significant difference between the two groups (P<0.05).

Conclusion: Wuling capsule can effectively inhibit the release rate of inflammatory factor, reduce the expression level of related inflammatory factors, effectively improve the fatigue after stroke and promote the early rehabilitation. It has a reference value in clinical practice.

Author(s): Liu Fengli, Li Yan, Xu Yanli
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