Biomedical Research

Objective: To investigate the significance of tumor molecular marker matrix metallopeptidase 9 (MMP-9) combined with iconography in the staging of esophageal cancer.

Methods: The clinical staging of 108 esophageal careinoma patients were detected by CT image. The protein level of MMP-9 was determined by immunohistochemistry. The correlation of MMP-9 and clinical staging of esophageal careinoma was analyzed.

Results: Positive expression rate of MMP-9 was 60.19% in biopsy tissue of esophageal carcinoma, while 78.00% in patients in stage T3-T4 was higher than that in T1-T2 stage (43.10%, P<0.01). Positive expression rate of MMP-9 in lymph metastasis group (N1) was 90.91%, which was higher than that in non-lymph metastasis group (N0, 43.40%, P<0.01). Positive rate of MMP-9 was 94.12% in clinical III-IV phase, which was higher than that in stage I-II (47.30%, P<0.01). The correlation coefficient were 0.389, 0.496, 0.461 between MMP-9 protein expression and stage T, N, TNM, respectively,and presented positive correlation (P<0.05).

Conclusion: MMP-9 expression has increased in late stage tumor.

Author(s): Hua Xu, Qiong-Ying Dai, Xiao-Dong Luo, An-Wen Liu, Zhihua Liu
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