Biomedical Research

Objective: To evaluate the impact of obesity on the living quality and the complications risk in T2DM patients.

Methods: A total of 1000 patients with T2DM were observed for a median follow-up period of more than 3 years (less than 4 years). In the cohort, there were 500 patients who were obese (30 kg/m²) as obesity group, and other 500 normal weight (18.5 kg/m²) patients who were paired with the obesity group (non-obesity group). The living quality and incidence of complication in the follow-up period between two groups was compared. Relative risk of T2DM complications between two groups was calculated.

Results: The patients in Non-obesity group had better score than those in the obesity group (P<0.05). We follow up the primary complications of all the patients. The result showed that the incidence in the obesity group was significantly higher in the comparison of cerebrovascular (19.80% vs. 10.40%, t=17.23, P<0.05), peripheral artery (17.40% vs. 8.60%, t=17.12, P<0.05), cardiovascular (14.00% vs. 7.60%, t=10.63, P<0.05) and renal (9.20% vs. 5.60%, t=4.73, P<0.05) complications. Moreover, patients in the obesity group have higher risk in the cerebrovascular (RR=5.58, 95% CI ((3.58~9.25)), peripheral artery (RR=5.49, 95% CI (3.40~8.59)), cardiovascular (RR=2.25, 95% CI (1.29~5.43)) and renal complications (RR=2.10, 95% CI (1.18~5.06)) than that in the non-obesity group.

Conclusions: T2DM patients with obesity will have great possibilities poor outcome in living quality; T2DM patients with obesity will have higher risk in diabetes complication.

Author(s): Fan Linlin, Liu Yaping, Yu Jixiang, Lu Ying, Zhao Jie, Sun Fengjuan, Mi Na, Wu Junli
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