Biomedical Research

Objective: To discuss the therapeutic effects of DDP and fluorouracil in Nasopharyngeal Carcinoma (NPC).

Methods: 40 patients with NPC who were treated in our hospital from January 2014 to August 2017 were chosen as the research objects and divided into two groups in line with the random number table. 40 patients in the control group were treated with the concurrent radiochemotherapy and 40 patients in the observation group were treated with DDP+fluorouracil (PF) combining with concurrent radiochemotherapy. Therapeutic effects, distant metastasis, local recurrence, five-year survival rate and untoward effects of patients in both groups were observed.

Results: 34 patents had Complete Remission (CR) and 5 patients had Partial Remission (PR) in the observation group. The total control ratio was 97.5%. There were 26 patients with CR and 7 patients with PR in the control group. The total control ratio was 82.5%, P<0.05. Five-year OS and PFS in the observation group were 87.5% and 85%, respectively and those of the control group were 75% and 82.5%, respectively, P<0.05. The occurrence of nausea and vomiting and leukocyte ↓ of patients in both groups had the significant difference, P<0.05. There was no significant difference in other untoward effects, P>0.05.

Conclusions: PF scheme concurrent radiochemotherapy significantly improved local control ratio of NPC and obviously enhanced five-year survival rate of patients, but untoward effects in the therapeutic process should be noticed to ensure curative effects.

Author(s): Lin Meng, Mingming Yang, Xingde Tian, Bi Qiang
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