Biomedical Research

Cervical cancer is one of the most common malignant tumors in female only second to breast cancer. There are several methods for cervical cancer screening. Free body of iron protoporphyrin reduced state (FH) is used in the screening of cervical intraepithelial neoplasia in different stages. However, there is still lack of investigation about the diagnostic value of epithelial cell stable FH in cervical cancer. Epithelial cell FH staining kit was used to test epithelial cell FH. Pathology was selected as the golden standard for cervical cancer diagnosis. Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were calculated. Receiver Operating Characteristic (ROC) curve was adopted to analyse the diagnostic value of FH on cervical cancer. The detection sensitivity of FH was different in Cervical Intraepithelial Neoplasia (CIN) at different stages. Sensitivity was higher, while specificity was lower following malignancy upgrading. Combining correct index and Kappa value, FH showed great diagnostic value for CIN and cervical cancer with different malignant potential. Area Under the Curve (AUC) of FH on CIN I, CIN II, CIN III, and cervical squamous cell carcinoma was 0.761, 0.825, 0.815, and 0.877, respectively (P<0.01). Epithelial cell stable FH detection was an important supplementary mean for cervical cancer diagnosis.

Author(s): Jimin Ma, Cuiqing Chai, Yuqing Liu, Mei Song, Zhenhua Yin, Aihua Li
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