Biomedical Research

Objective: This research aimed to observe and analyze the clinical effect of hemopurification on emergency patients with severe organophosphorus poisoning.

Method: Eighty-four patients with severe organophosphorus poisoning who accepted treatment in our hospital from January 2015 to December 2016 were selected. Random number table was used to equally divide these patients into observation group (n=42) and control group (n=42) in which the former was given with conventional emergency treatment, and the latter accepted hemopurification treatment. Then, the curative effects of the two groups were compared.

Results: The total effective rate in treatment of patients in the observation group was significantly higher than that in the control group (P<0.05). The blood biochemical indexes of patients in the observation group were significantly superior to those in the control group (P<0.05). The atropine dosages of patients in the observation group were significantly less than those in the control group (P<0.05). The autonomous respiratory recovery time, consciousness recovery time, and the length of stay (LOS) of patients in the observation group were significantly shorter than those in the control group (P<0.05). The white blood cell (WBC), blood urea nitrogen (BUN), C-reactive protein (CRP), and creatinine (Scr) levels of patients in both groups were significantly lowered (P<0.05), and those of patients in the observation group were significantly lower than those in the control group (P<0.05).

Conclusion: Hemopurification treatment based on conventional emergency treatment had favourable curative effect on patients with severe organophosphorus poisoning, and it could effectively improve the blood biochemical indexes of the patients and shorten recovery time. Thus, hemopurification gained clinical popularity because of its significant applications.

Author(s): Kai Guo, Ting-Ting Gao, Guang-Xin Chen, Chao Wang
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