Biomedical Research

Objective: To investigate the effects of alprostadil on the efficacy, liver function, inflammatory response, caspase-3 and ICAM-1 in acute liver injury of sepsis.

Methods: Case data of sixty-nine (69) patients with acute liver injury of sepsis in our hospital from January, 2014 to December, 2016 were analysed retrospectively, of whom, 30 cases were given routine anti-sepsis and recruited into the control group. 39 cases were given alprostadil treatment on the basis of the control group and recruited into the observation group. Then liver function, inflammation reaction and caspase-3 and ICAM-1 changes before and after treatment in the two groups were observed.

Results: There were no statistical differences in APACHEII score between the two groups before treatment in two groups (P>0.05). There were significant statistical differences in APACHEII score between the two groups before and after treatment (P<0.05). After three and seven days’ treatment in the observation group, APACHEII score lower than the control group obviously. Differences between groups were obvious (P<0.05). There were no significant statistical differences between groups before treatment with respect to ALT and AST levels (P>0.05). There were significant statistical differences between groups before and after treatment with respect to ALT and AST levels (P<0.01). After three and seven days’ treatment in the observation group, ALT higher than the control group obviously, after seven days’ treatment in the observation group, ALT higher than the control group obviously, differences between groups were obvious (P<0.05). TNF-α in the two groups before treatment had no obvious differences (P>0.05), and there were statistical differences before and after treatment in the two groups (P<0.05). After three and seven days’ treatment, TNF-α level in the observation group lower than the control group, differences between groups were obvious (P<0.05). There were no significant differences before treatment between groups with respect to caspase-3 and ICAM-1 levels (P>0.05). There were statistical differences after treatment in two groups with respect to caspase-3 and ICAM-1 levels (P<0.05), After one, three and seven days’ treatment in the observation group, caspase-3 and ICAM-1 levels lower than the control group obviously, differences between groups were obvious (P<0.05).

Conclusion: Alprostadil in treating acute liver injury of sepsis can promote recovery of liver function effectively and relieve inflammatory reaction caused by sepsis.

Author(s): Yuan Xiaoyu, Yuan Juping, Huang Zhongwei
Abstract | Full-Text | PDF

Share this