Biomedical Research

Objective: To determine the optimum blood glucose target values between two classic glycemic control goals and compare their efficacy and safety in patients with Severe Acute Pancreatitis (SAP).

Methods: 112 SAP patients included in the study were randomly divided into two groups: group A for a blood sugar control target value of 7.8-10 mmol/L and group B for a blood glucose control target value of 6.1-8.3 mmol/L. The glycemic control parameters, prognostic parameters and adverse events during glycemic control were compared.

Results: Group A achieved glycemic control goals more quickly than group B, and had significantly less severe hypoglycemic events and glucose treatment events (p<0.05). No significant differences in moderate/severe malnutrition rates, the incidence of infection, MODS incidence, the average ICU stay, 28 day mortality, and hyperglycemic parameters were observed (p>0.05) between the two groups.

Conclusion: Glycemic control target of 7.8-10 mmol/L can reduce the risk of hypoglycemia in patients with SAP and is achieved faster and more safely than a glycemic control target of 6.1-8.3 mmol/L.

Author(s): Yue-lan Qin, Ze-ya Shi, Si-yuan Tang, Yan-hui Liu, Yi-min Zhu, Xu Zhou, Bo Jiang, Min-hui Liu, Sek-Ying Chair
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