Biomedical Research

Objective: To observe plasma ANP level of patients with ASD, VSD and PDA after interventional occlusion, analyse plasma ANP level value of reflection on cardiac structure and cardiac function changes of patients with ASD, VSD and PDA after interventional occlusion.

Methods: 60 infantile patients with CHD were recruited into CHD group, right ventricular function was examined by UCG in the first and second day, first and third month after surgery. Plasma ANP expression level was detected by using ELISA. In addition, 30 healthy people by examination were recruited as NC group and were given relevant examination.

Results: Plasma ANP expression level by ELISA showed that compared with NC group, ANP level of infantile patients in various groups increased in different levels in the first day before surgery, the third day and first month after surgery (P<0.05-0.01). The third month after surgery was tending to be stable. There were no significant differences compared with NC group; compared with the first day before surgery, plasma ANP level obviously decreased the third day after interventional occlusion (P<0.05), it decreased in the first month and third month after surgery (P<0.01). UCG found that, compared with NC group, right ventricular volume in diastasis stage, right ventricular volume and right ventricular ejection fraction in end-systole period all significantly increased (P<0.05-0.01). In the third month after surgery, various indexes tended to be stable. There were no significant differences compared with NC group; compared with the first day before surgery, right ventricular volume in diastasis stage, right ventricular volume and right ventricular ejection fraction in end-systole period all obviously decreased in the third day after surgery (P<0.05); in the third and sixth day after surgery, right ventricular volume in diastasis stage, right ventricular volume and right ventricular ejection fraction in end-systole period obviously decreased compared with before surgery (P<0.01).

Conclusion: After interventional occlusion, plasma ANP level of infantile patients with ASD, VSD and PDA are detected, which is benefit for evaluating recovery conditions of heart structure and cardiac function in infantile patients.

Author(s): Zhang Shenwei, Li Chunling, Zhang Zheng, Guo Jing, Li Jing, Qin Yanping, Qiu Chunguang, Yuan Yiqiang
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