Biomedical Research

Objective: To investigate the clinical value of combined detection of routine blood, biochemical markers and tumor markers for screening of patients with gastric cancer.

Methods: A total of 106 patients with gastric cancer treated in our hospital from February 2016 to September 2017 were selected as study group, with another 90 healthy subjects undergoing physical examination during the same period as control group. The changes in blood routine, biochemical markers in serum and tumor markers were comparatively analyzed between the 2 groups.

Results: Compared with the control group, the levels of white blood cell (WBC) and platelet (PLT) count in the blood routine were significantly improved in the study group, with the difference being statistically significant (P<0.05); while the level of hemoglobin (Hb) was decreased in the study group of no statistical significance(P>0.05); the levels of Total Cholesterol (TC), High-density lipoprotein cholesterol (HDL-C) and Low-density lipoprotein cholesterol (LDL-C) in biochemical indexes were significantly decreased in the study group, with the difference being statistically significant (P<0.05); and the levels of such tumor markers as carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125) and carbohydrate antigen 199 (CA199) level were significantly increased in the study group of statistical significance (P<0.05).

Conclusion: The combined detection of blood routine, biochemical indexes and tumor markers is of important reference value for screening of patients with gastric cancer and can provide the basis for early treatment of the disease.

Author(s): Xiao Ying, Jianling Zheng, Zhenhua Wang, Zaihong Wang, Xiaoyu Xu
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