Biomedical Research

This work aims to investigate the changing characteristics of calcium-regulating hormones and bone turnover markers (BTMs) among Han-Chinese men in a Beijing community. A retrospective analysis was carried out by studying the general information and the data of calcium- regulating hormones (25-hydroxyvitamin D [25(OH)D], parathyroid hormone [PTH]) and bone turnover markers (procollagen type 1 amino-terminal propeptide [P1NP], osteocalcin [OC] and C-terminal cross-linking telopeptide [CTX]) from 2792 Han-Chinese men, who were selected from those attending routine physical examinations in a Beijing community. The effect of vitamin D status on the bone turnover markers was investigated. For the sample population (aged 24 to 97 years), serum concentrations of 25(OH)D were found to be 19.84±8.65 ng/ml. The serum PTH concentration showed a tendency to increase with age and was negatively associated with serum calcium concentrations (r=-0.3192, P < 0.0001). The levels of P1NP were found to decrease with age (P < 0.01), so was the level of CTX (P < 0 01). The level of OC reached a maximum at 40-49 years of age, and then declined with age (P < 0.01). It was shown that the bone turnover markers were negatively associated with 25(OH)D: OC (r=-0.1690, P < 0.0001), P1NP (r=-0.1799, P < 0.0001) and CTX (r=-0.1822, P < 0.0001). Among the Han-Chinese men, the bone turnover markers increased with age, and were negatively associated with 25(OH)D.

Author(s): Yu Pei, Yanhui Lu, Minyan Liu, Fusheng Fang, Xiaoling Cheng, Lichao Ma, Wenwen Zhong, Jian Li, Chunlin Li
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