Biomedical Research

Translation of basic research into cell-based therapies in tissue regeneration

Joint Event on 2^nd International Conference on Tissue Science and Molecular Biology, Stem Cells & Separation Techniques
June 06-07, 2019 | London, UK

Madhu Dhar, David E Anderson, Henry S Adair, James Schumacher and Dennis Geiser

University of Tennessee, USA

Posters & Accepted Abstracts : Biomed Res

Abstract:

The large animal regenerative medicine program, started in 2010 conducts research in the use of mesenchymal stem cells, biomaterials and other forms of cell-based therapies that will translate to both veterinary and human medicine. Our ultimate goal is to make basic discoveries and to expand these discoveries into the development of diagnostic modalities and treatment protocols to solve complex medical problems related to musculoskeletal, and nerve injuries. We carry out specific in vitro assays to evaluate cell adherence, proliferation and potential for differentiation into osteocytes, chondrocytes or neural-like progenitors. We then conduct controlled studies, using rodents, to confirm the biocompatibility and efficacy of mesenchymal cells used alone or in combination with biomaterials. Finally, we translate these findings into controlled, preclinical studies using large animals, including goats, sheep, pigs and horses. We perform the in vitro and rodent studies to improve clinical outcomes for large animal and human patients.

Biography:

E-mail:

mdhar@utk.edu

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