Biomedical Research

Purpose: It aims to explore the influence of dexmedetomidine on stress level and postoperative cytokines of laparoscopic operation for colorectal cancer of senile patients with general anesthesia.

Method: 60 cases of patients of 65-80 y old with ASA levels of I-II who are planned to be conducted with laparoscopic operation for colorectal cancer are selected and divided into the Dexmedetomidine group and the saline group, 30 cases for each group. The patients of the dexmedetomidine group are injected with Dexmedetomidine of 0.4 μg/kg with venous pumps before anesthesia induction within 10 min, and Dexmedetomidine of 0.4 μg•kg^-1•h^-1 is in combined during maintenance of anesthesia. The patients of the saline group are applied with normal saline of equivalent quantity. The Mean Arterial Pressure (MAP), Heart Rate (HR) and Cortisol (Cor) are recorded at entrance (T0), after injection of dexmedetomidine (T1), immediately after the tracheal intubation (T2), pneumoperitoneum (T3) and immediately after tracheal extubation (T4); the interleukin-6 (IL-6) and interleukin-10 (IL-10) at T0, T4, 24 h after operation (T5) and 48 h after operation (T6) are also recorded.

Results: The MAP and HR levels of the dexmedetomidine group at T1-4 are significantly lower than that of the saline group (P<0.05); the Cor level of the Dexmedetomidine group at T2-4 is significantly lower than that of the saline group (P<0.05); the IL-6 level of the dexmedetomidine group at T4-6 is significantly lower than that of the saline group (P<0.05); the IL-10 level of the dexmedetomidine group at T4-6 is significantly lower than that of the saline group (P<0.05).

Conclusion: Dexmedetomidine can be applied to laparoscopic operation for colorectal cancer of senile patients with general anesthesia, which is beneficial to the relieving of stress response by reducing the release of Cor; in addition, it helps relieve the release of the proinflammatory factor IL-6 and increase that of the postoperative anti-inflammatory factor IL-10, maintaining the balance of cytokines.

Author(s): Wang Lei, Ding Yanling, Li Aijun, Lu Zhufeng, Bai Yanhui
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