Biomedical Research

Aims: The present study is to investigate the value of multi-slice spiral computed tomography (MSCT) in the differentiation of benign and malignant solitary pulmonary nodule (SPN).

Methods: A total of 21 patients with benign SPN and 21 patients with malignant SPN were included in the present study. MSTC perfusion imaging characteristics and parameters were analyzed. For imaging analysis, shapes, locations, borders, density and enhancement of lesions were investigated. After choosing the region of interest on the images, perfusion parameters, time-density curve and hemodynamic parameters such as blood flow, blood volume, mean transit time, and permeability of surface were evaluated.

Results: Patients with malignant SPN had greater blood flow, blood volume, mean transit time, and permeability of surface than those with benign SPN. CT manifestations of malignant SPN were distinct from those of benign SPN. Patients with malignant SPN had even enhancement but those with benign SPN had thin wall ring enhancement or no enhancement. Malignant SPN had distinct perfusion parameters and time-density curve compared with benign SPN. Peak height and mass/aorta peak ratio were efficient in differentiating benign and malignant SPN.

Conclusions: The present study demonstrates that MSCT perfusion imaging technology provides the imaging information of SPN. More importantly, hemodynamics and time-density curves of SPN are effective in the differentiation of benign and malignant SPN. MSCT is helpful in the early treatment of SPN, promoting the survival rate and improving the prognosis of SPN patients.

Author(s): Gang Wang, Xiaoming Zhou, Ruirui Zhao, Wenjian Xu, Chuanyu Zhang, Gang Jiang, Xiaoyan Tang, Hualong Yu
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