Biomedical Research

Objective: To study the curative effect of continuous intravenous drip of low molecular dextran combined with furosemide in the treatment of edema in children with nephrotic syndrome.

Methods: A total of 170 children with edema in nephrotic syndrome treated in the Pediatric Department of our hospital from March 2015 to May 2017 were randomly divided into two groups. Patients in control group were treated with intravenous drip of furosemide (furosemide injection), while those in experimental group received intravenous drip of low molecular dextran based on the treatment in control group. The treatment indexes of the two groups were summarized.

Results: At 7 d after treatment, the total effective rate of treatment in experimental group was 97.15%, which was higher than that in control group (88.24%, P<0.05). The extinction time of edema in experimental group was shorter than that in control group, the 24-h urine volumes at 3 d, 5 d and 7 d after treatment were larger than those in control group, and the 24-h urinary protein level was lower than that in control group (P<0.05). During the 6-month follow-up, the recurrence rate in experimental group was lower than that in control group (P<0.05).

Conclusion: Low molecular dextran combined with furosemide is significantly effective in the treatment of edema in children with nephrotic syndrome, which promotes the extinction of edema and improves the renal function, so it is worth promoting.

Author(s): Shipin Feng
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