Biomedical Research

Objective: To investigate the relationship between CT features and serum GFAP, NSE and S100B protein in patients with severe traumatic brain injury.

Methods: 80 patients with traumatic brain injury admitted in our hospital from January 2016 to January 2017 were selected and divided into mild (n=31), medium (n=28) and severe (21) according to their CT scores. The level difference between the three kinds of serum CFAP and between NSE and S-100B proteins, changes of three kinds of serum protein before and after treatment in patients with severe, and the relationship between the brain CT score and serum CFAP, NSE and S-100B protein analysis.

Results: The serum levels of CFAP, NSE and S-100B were significantly different in patients with different types of traumatic brain injury (P<0.05); the difference of CFAP, NSE and S-100B protein levels in patients with severe disease before and after treatment was statistically significant (P<0.05); by correlation analysis, the head CT score of patients with traumatic brain injury was positively correlated with CFAP, NSE and S-100B protein.

Conclusion: In patients with traumatic brain injury by CT score and serum CFAP, NSE, S-100B protein level has a positive correlation, which has a certain guiding significance of changes of serum CFAP, NSE, S-100B protein level identification and prognosis of patients with traumatic brain injury.

Author(s): Qiaoke Li, Qi Zhou
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