Biomedical Research

Background: It is suggested that microvascular invasion (MVI) is one of the strongest predictors of prognosis and recurrence of hepatocellular carcinoma (HCC). This study analyzes the related influence factors of MVI, and further discusses these factors to the occurrence of MVI.

Method: Retrospective clinical data of HCC patients which are collected, including the general clinical data and postoperative pathological data associated with MVI are performed. According to the postoperative pathological report, data will be divided into MVI group and control group. Logistic regression analysis was performed on the statistically significant factors.

Results: A total of 170 patients with HCC are selected. There are MVI group (51 cases) and control group (97 cases). There were no significantly differences in age, gender, history of hepatitis B, history of hepatitis C, hepatic cirrhosis, diabetes and hepatitis B virus deoxyribonucleic acid titer, γ- glutamyltranspeptidas, alanine transaminase, aspartate transaminase, total bilirubin, albumin, platelet count, tumor numberand tumor capsule (P>0.05). Tumor size (P=0.000), differentiation degree (P=0.028) and alpha-fetoprotein (P=0.003) was statistically significant difference. Multivariate logistic regression analysis shows that tumor size (P=0.004) and AFP (P=0.022) are independent risk factors for MVI.

Conclusion: Tumor size, low differentiation, tact capsule and alpha-fetoprotein are independent risk factors of MVI. According to the risk factors of MVI, we can judge the possibility of MVI, and further guide the clinical treatment.

Author(s): Yan Zhang, Wanjing Yang, Jingli Ren
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