Biomedical Research

Objective: To investigate the correlation between the levels of homocysteine, blood lipids and inflammatory markers and the carotid plaque in patients with ischemic cerebrovascular disease.

Methods: 56 cases of patients with ischemic cerebrovascular disease admitted by this hospital from October 2010 to October 2013 were categorized as a case group while 56 cases of healthy physical examinees of similar age and sex ratio were chosen as the control group. Based on color Doppler ultrasound results in carotid artery, the two groups were subdivided into carotid plaque group and noplaque group respectively. Levels of homocysteine, blood lipids and inflammatory markers of every group were measured.

Results: The case number of carotid plaque and IMT (Intimal Medial Thickness) in the case group is larger than those of the control group, which is statistically significant in difference (P<0.05). Levels of blood lipid TC, LDL and three inflammatory markers (Hs-CRP, IL-6 and Fbg) and homocysteine in the case group are higher than those in control group, which is statistically significant in differences (P<0.05). Levels of Lipids TC, LDL and three inflammatory markers (Hs-CRP, IL-6 and Fbg) and homocysteine in the plaque group of the case group are higher than those in the no-plaque group of the case group, which is statistically significant in differences (P<0.05). Levels of Lipids TC, LDL and three inflammatory markers (Hs-CRP, IL-6 and Fbg) and homocysteine in the plaque group of control group are higher than those in the no-plaque group of control group, which is statistically significant in differences (P<0.05). Levels of Lipids TC, LDL and three inflammatory markers (Hs-CRP, IL-6 and Fbg) and homocysteine of the plaque group are higher than those in the no-plaque group of the case group, which is statistically significant in differences (P<0.05).

Conclusion: Levels of homocysteine, blood lipids, and inflammatory markers in patients with ischemic cerebrovascular disease are closely associated with different properties of carotid plaque.

Author(s): Weibo Zheng, Wenfang Xu, Xiaohua Wang, Jiangfeng Chen, Qiong Tan
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