Biomedical Research

Objective: To study the effect of pterygium on corneal refractive status and therapeutic effect of autologous corneal limbus stem cells transplantation on refractive status and vision of patients in clinical treatment of pterygium.

Methods: 80 cases of patients with pterygium in our hospital from June to September in 2014 were chose, with a total of 96 suffering eyes, to be randomly divided into observation group and control group (n=40). The control patients underwent pterygium excision surgery, while observation group were treated with excision surgery combined with autologous corneal limbus stem cell transplantation. Corneal refractive status and naked-eye eyesight of patients of two groups before and after surgery were compared and analysed.

Results: After surgery, corneal refractive status and naked-eye eyesight of patients of two groups were improved than that before, as well as a significant improvement of corneal photometric (P<0.05); At 1, 2, 3 and 4 weeks after operation, the naked eye eyesight of patients in observation group were (0.48 ± 0.07), (0.65 ± 0.13), (0.94 ± 0.11) and (1.12 ± 0.13), respectively, with significant statistical difference compared with the control group contemporaneity (P<0.05); The diopters of observation group were respectively (2.89 ± 0.48), (1.63 ± 0.52) before and after operation, suggesting great decline to the control group ((2.72 ± 0.56)v (1.93 ± 0.49)) with the significant difference (P<0.05).

Conclusion: Pterygium excision combined with autologous limbal stem cell transplantation treatment can effectively improve the astigmatism of the patients, enhance the naked eyesight and reduce the disease recurrence, which is worthy of promotion and application.

Author(s): Gao Peng, Hou Ping, Wang Fang
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