Biomedical Research

Objective: To observe and analyse the therapeutic effect of superselective interventional chemotherapyradiotherapy combined treatment on reducing in number or eliminating postoperative residual cells in brain glioma.

Methods: Fifty-two patients with brain glioma, which were advised to undergo tumor resection in our hospital from January 2014 to January 2016, were selected and divided into observation (n=28) and control groups (n=24) according to patient preference. The observation group was given superselective interventional chemotherapy-radiotherapy combined treatment, whereas the control group was managed with systematic radiotherapy-chemotherapy treatment. The respective therapeutic effects were then compared between the two groups.

Results: The therapeutic effects on the observation group were significantly superior to those on the control group (P<0.05); however, the incidences of adverse reactions were insignificantly different (P>0.05). The prognostic effects were significantly greater in the observation group than in the control group (P<0.05). The Karnofsky grades (71.78 ± 4.83) were significantly higher in the observation group than in the control group (59.93 ± 5.17) (P<0.05).

Conclusion: Superselective interventional chemotherapy-radiotherapy combined treatment can effectively reduce and eliminate postoperative residual cells and produce a favorable prognostic effect in patients with brain glioma.

Author(s): Xin-Ying Shen, Jian Kong, Yan-Fang Zhang, Xu-Dong Chen
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